Fig. 7

ABCE1 interacts highly associated targets and functional annotations in COAD datasets. (A) CTD database (n = 253), GSE33113 (n = 3415), and gene cards (n = 1734) retrieval of target genes were illustrated as Venn diagram denotes commonly overlapping targets (n = 64) which are strongly associated with ABCE1. (B) Using STRING, web-server for protein-protein interaction was visualized. (C) The interaction file was illustrated in cytoscape software. The diagram shows the association of potent targets by interaction of ABCE1. (D) Using MCODE plugin the PPI has scrutinized. (E and F) Using ClustVis, plugin scrutinized top 15 hub genes in accordance to their Rank (1), nodes (15), edges (120), modularity (2.308), InDeg (120), and their OutDeg (52), indicated in green color. (G) The functional annotation (GO) was visualized in bubble chart (BP, CC, MF) according to their p value and gene count. (H) Butterfly plot represents the highly enriched pathways from KEGG (Pink color) and Reactome (Brown color) with the top 15 genes by their enrichment score (-log₁₀(p value)). CTD, Comparative Toxicogenomic Database; GO – Gene Ontology; BP, Biological Processes; CC, Cellular Component; MF, Molecular Functions.