Table 2 Multifactor regression analysis of PAC and blood lipids in PA patients.

From: The association between aldosterone and lipid profiles in patients with primary aldosteronism

Variables

PA group β/OR (95% CI) P value

Not adjusted

Adjustment I

Adjustment II

Log TC

Log PAC

 − 0.110 (− 0.170, − 0.051) 0.0003

 − 0.111 (− 0.171, − 0.052) 0.0003

 − 0.076 (− 0.142, − 0.010) 0.0256

Q1

Reference

Reference

Reference

Q2

 − 0.030 (− 0.056, − 0.004) 0.0269

 − 0.030 (− 0.056, − 0.004) 0.0243

 − 0.025 (− 0.052, 0.001) 0.0625

Q3

 − 0.041 (− 0.067, − 0.015) 0.0024

 − 0.042 (− 0.068, − 0.016) 0.0017

 − 0.024 (− 0.052, 0.003) 0.0872

P for trend

0.002

0.002

0.077

log TG

Log PAC

 − 0.184 (− 0.355, − 0.014) 0.0351

 − 0.194 (− 0.359, − 0.029) 0.0221

 − 0.176 (− 0.352, − 0.001) 0.0497

Q1

Reference

Reference

Reference

Q2

 − 0.065 (− 0.139, 0.009) 0.0881

 − 0.070 (− 0.142, 0.002) 0.0581

 − 0.045 (− 0.115, 0.026) 0.2139

Q3

 − 0.090 (− 0.165, − 0.016) 0.0177

 − 0.092 (− 0.164, − 0.020) 0.0129

 − 0.062 (− 0.136, 0.012) 0.1009

P for trend

0.018

0.013

0.096

log HDL-C

Log PAC

 − 0.020 (− 0.102, 0.061) 0.6210

 − 0.012 (− 0.084, 0.061) 0.7502

0.014 (− 0.066, 0.094) 0.7268

Q1

Reference

Reference

Reference

Q2

 − 0.009 (− 0.045, 0.026) 0.5993

 − 0.005 (− 0.037, 0.027) 0.7569

 − 0.001 (− 0.033, 0.031) 0.9685

Q3

0.007 (− 0.028, 0.043) 0.6834

0.009 (− 0.022, 0.041) 0.5695

0.020 (− 0.013, 0.054) 0.2355

P for trend

0.683

0.568

0.250

log LDL-C

Log PAC

 − 0.130 (− 0.218, − 0.042) 0.0040

 − 0.133 (− 0.220, − 0.046) 0.0031

 − 0.087 (− 0.186, 0.011) 0.0827

Q1

Reference

Reference

Reference

Q2

 − 0.043 (− 0.081, − 0.005) 0.0276

 − 0.046 (− 0.084, − 0.008) 0.0194

 − 0.037 (− 0.077, 0.002) 0.0645

Q3

 − 0.059 (− 0.097, − 0.020) 0.0029

 − 0.061 (− 0.099, − 0.023) 0.0017

 − 0.040 (− 0.082, 0.001) 0.0553

P for trend

0.003

0.002

0.049

log Non-HDL

Log PAC

 − 0.140 (− 0.217, − 0.063) 0.0004

 − 0.144 (− 0.221, − 0.067) 0.0003

 − 0.105 (− 0.191, − 0.018) 0.0184

Q1

Reference

Reference

Reference

Q2

 − 0.037 (− 0.071, − 0.004) 0.0299

 − 0.039 (− 0.073, − 0.006) 0.0226

 − 0.034 (− 0.069, 0.000) 0.0539

Q3

 − 0.058 (− 0.092, − 0.024) 0.0008

 − 0.060 (− 0.094, − 0.026) 0.0006

 − 0.040 (− 0.076, − 0.004) 0.0317

P for trend

 < 0.001

 < 0.001

0.028

  1. Adjustment I: adjusted for sex, age, and BMI.
  2. Adjustment II: adjusted for sex, age, BMI, duration of hypertension, diabetes mellitus, smoking history, drinking history, using antihypertensive drugs, Blood potassium, eGFR, Fasting blood glucose, glycosylated hemoglobin, Standing PRA, 24 h mean SBP, 24 h mean DBP.
  3. PAC, TG, TC, HDL-C, and LDL-C, were log-transformed with base 10. Q1, Q2, and Q3 represent three equal groups of cases based on log PAC values. In the PA group, log PAC ≤ 1.335 in Q1 (n = 89), 1.335 < log PAC ≤ 1.486 in Q2 (n = 89), and log PAC > 1.486 in Q3 (n = 89).
  4. EH essential hypertension, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, PAC plasma aldosterone concentration, PA primary aldosteronism, TC total cholesterol, TG triglycerides.
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