Table 4 Summary of studies evaluating the efficacy of salvage chemotherapy in patients with advanced esophageal squamous cell carcinoma.

From: The efficacy and safety of FOLFOX therapy for advanced esophageal squamous cell carcinoma

Author

n

Study type

Treatment regimen

ORR (%)

DCR (%)

MST (m)

Ref

Nomura, et al.

16

Retro

Fluorouracil or S-1

13.3

66.7

12.9

18

147

BSC

NA

NA

4.3

Akutsu, et al.

20

Retro

S-1

25

60

10.8

19

Tamaoki, et al.

15

Retro

S-1

6.6

66.7

10

20

Ito et, al.

11

Retro

S-1

22.2

36.4

11.7

21

Nomura, et al.

16

Phase 2

S-1

13.3

46.7

8.4

22

Present study

39

Retro

FOLFOX

4

36

7.4

 
  1. ORR: overall response rate, DCR: disease control rate, MST: median survival time, m: months, Ref: reference, Retro: retrospective, NR: not reached.