Table 1 Atom economy, environmental factors, product mass intensity for monomeric, dimeric amide-based pyridinium bromides.
From: Solid-phase synthesis and cytotoxic evaluation of novel pyridinium bromides
Compound | No of steps | Overall yield (%) | Overall AE (%) | E-factor | E-Solvent | E- Solvent free | E-Catalyst | Product mass intensity with solvent (PMI) Total | Product mass intensity solvent free (PMISF) Total |
|---|---|---|---|---|---|---|---|---|---|
2 | 1 | 86 | 100 | 0 | 41.01 | 0 | 0 | 1.0 | 0 |
3 | 1 | 88 | 100 | 0 | 41.01 | 0 | 0 | 1.0 | 0 |
4 | 1 | 87 | 100 | 0 | 41.01 | 0 | 0 | 1.0 | 0 |
5 | 1 | 85 | 100 | 0 | 41.01 | 0 | 0 | 1.0 | 0 |
6 | 1 | 86 | 100 | 0 | 41.01 | 0 | 0 | 1.0 | 0 |
