Table 3 Probabilities for drug-likeness properties of amide-based monomeric and dimericpyridinium bromides 1–6 predicted by Lipinski’srule of five”.

From: Solid-phase synthesis and cytotoxic evaluation of novel pyridinium bromides

Compd

Mass (g/mol)

(< 500)

Number of hydrogen bond acceptors (≤ 10)

Number of hydrogen bond donors

(≤ 10)

Log P (≤ 5)

TPSA

(≤ 140) Å

1

212.25

2

1

2.16

41.99

2

668.46

2

2

1.39

65.96

3

688.45

2

2

1.55

65.96

4

641.63

2

2

1.85

65.96

5

428.28

3

1

0.93

78.8

6

411.29

2

1

1.52

50.05

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