Table 4 ADME properties of amide-based monomeric and dimeric pyridinium bromides 1–6.
From: Solid-phase synthesis and cytotoxic evaluation of novel pyridinium bromides
Compd | Water solubility | Lipophilicity (LogPo/w) | Skin permeation (LogKp) | GI Absorption | BBB permeation | p-gp substrate | Drug likeness |
|---|---|---|---|---|---|---|---|
1 | Soluble | 2 | − 6.12 | High | Yes | No | Yes |
2 | Poorly soluble | − 9.71 | − 5.14 | High | No | Yes | Yes |
3 | Poorly soluble | − 9.04 | − 5.12 | High | No | Yes | Yes |
4 | Poorly soluble | − 11.17 | − 4.3 | High | No | Yes | Yes |
5 | Moderately soluble | − 4.3 | − 5.66 | High | No | Yes | Yes |
6 | Moderately soluble | − 3.76 | − 5.5 | High | No | Yes | Yes |
