Fig. 8 | Scientific Reports

Fig. 8

From: Protein disulfide isomerase integrates toll-like receptor 4 and P2X7 receptor signaling pathways during lipopolysaccharide-induced neuroinflammation

Fig. 8

Scheme of roles of PDI in the integration of TLR4- and P2X7R-mediated signaling pathways during inflammation. LPS-induced TLR4 activation led to NF-κB activation by S-nitrosylation and phosphorylation of p65 subunit, which upregulated iNOS and PDI expression in microglia. S-nitrosylation of PDI induced by iNOS further augmented NF-κB activation by a direct interaction as well as the enhanced surface P2X7R expression, independent of S-nitrosylation of p65.

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