Fig. 5 | Scientific Reports

Fig. 5

From: Abundance and transmission of antibiotic resistance and virulence genes through mobile genetic elements in integrated chicken and fish farming system

Fig. 5

(A) Heatmap depicting the correlation between the top 25 most abundant mobile genetic elements (MGEs) and antimicrobial resistance genes (ARGs). Correlation analysis using Spearman correlation revealed several strong positive correlations, with MGEs such as Tn6072, Tn6246, and Tn4001 significantly correlating with ARGs like tetM, sulI, and tetX. Additionally, ICEBfrYCH46-1 showed a strong positive correlation with tetW and gyrA, highlighting the widespread co-association between MGEs and ARGs, which suggests their potential role in the dissemination of antibiotic resistance within microbial communities. (B) Heatmap illustrating the correlation between the top 25 virulence genes and mobile genetic elements. Correlation analysis revealed that the transposon element Tn125 and the plasmid Nonomuraea gerenzanensis isolate nono1 plasmid I exhibited positive correlations with multiple virulence genes, including pvdL, pvdI, chpA, and pchF, among others.

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