Table 3 Comparison of sensitivity and specificity of malaria Pan/Pf/Pv/IC LAMP-MS assay with commercial RealStar® malaria screen & type PCR kit against P. falciparum, P. vivax and non-infection clinical samples.
From: Development of a rapid malaria LAMP-MS assay for diagnosis of malaria infections
Clinical samples | Malaria Pan/Pf/Pv/IC LAMP-MS assay | RealStar® malaria screen & type PCR | ||||||
|---|---|---|---|---|---|---|---|---|
Pan | Pf | Pv | IC | Pf | Pv | IC | ||
P. falciparum (n = 80) | P/N | 78/80 | 80/80 | 0/80 | 80/80 | 0/80 | 80/80 | 80/80 |
Sensitivity [95% CI] | 97.5% [91.3–99.7] | 100% [95.5–100.0] | – | 100% [95.5–100.0] | – | 100% [95.5–100.0] | 100% [95.5–100.0] | |
Specificity [95% CI] | – | – | 100% [95.5–100.0] | – | 100% [95.5–100.0] | – | – | |
P. vivax (n = 80) | P/N | 76/80 | 0/80 | 75/80 | 80/80 | 80/80 | 80/80 | 80/80 |
Sensitivity [95% CI] | 95% [87.7–98.2] | – | 94% [86.0-97.9] | 100% [95.5–100.0] | 100% [95.5–100.0] | 100% [95.5–100.0] | 100% [95.5–100.0] | |
Specificity [95% CI] | – | 100% [95.5–100.0] | – | – | – | – | – | |
Non-infection (n = 100) | P/N | 0/100 | 0/100 | 0/100 | 100/0 | 0/100 | 100/0 | 100/0 |
Sensitivity [95% CI] | – | – | – | 100% [96.4–100.0] | – | 100% [96.4–100.0] | 100% [96.4–100.0] | |
Specificity [95% CI] | 100% [96.4–100.0] | 100% [96.4–100.0] | 100% [96.4–100.0] | – | 100% [96.4–100.0] | – | – | |
