Fig. 4 | Scientific Reports

Fig. 4

From: PKM2 accelerated the progression of chronic fatigue syndrome via promoting the H4K12la/ NF-κB induced neuroinflammation and mitochondrial damage

Fig. 4

PKM2 Enhances Glycolysis, Lactate Accumulation, and H4K12la/NF-κB-Mediated Neuroinflammation. A. Western blot analysis of PKM2, LDHB, H4K12la, P-P65, IL-1β, and TNFα protein expression in six groups of hippocampal cells: NC group (①), Lactate group (②), PKM2-OE group (③), PKM2-OE+3-BP group (④), PKM2-OE+3-BP+SN-50 group (⑤), and PKM2-OE+3-BP+activator-1 group (⑥).B. ELISA detection of IL-1β and TNFα levels in the supernatants of the six groups of hippocampal cells. (*P<0.05, **P<0.01, ns indicates no difference).

Back to article page