Fig. 1

L-Gln reduces serum cartilage degradation markers in rats with OA. A Experimental process of drug distribution and metabolism in rats. B, C Serum and synovium L-Gln concentration in rats (n = 5 per group). D Experimental protocol for comparative efficacy assessment of three drugs in OA rats. E–H Serum L-Gln, CTX-II, COMP, and IL-8 concentration in rrats at 12 weeks post-surgery (n = 5 per group). All data are represented as mean ± SD. ns = no significance * P < 0.05, ** P < 0.01, *** P < 0.001.