Fig. 3 | Scientific Reports

Fig. 3

From: Distinct metabolome and flux responses in the retinal pigment epithelium to cytokines associated with age-related macular degeneration: comparison of ARPE-19 cells and eyecups

Fig. 3The alternative text for this image may have been generated using AI.

Comparative metabolic pathway analysis between models. (A) Stacked bar chart of summed contribution of metabolites in each pathway to total metabolite abundance in A549 cells, ARPE-19 cells, and rat eyecups. For each model, the mean percentage of total metabolite abundance for each metabolite was calculated, and metabolites were summed based on their Kyoto encyclopedia of genes and genomes (KEGG)75 pathway with some modifications (see supplementary data). (B) Scatterplot showing pathway analysis of metabolites with significantly different abundance between ARPE-19 cells and eyecups. KEGG pathway impact scores are plotted on the x-axis and pathway enrichment significance is plotted on the y-axis. Points are coloured according to Log10 P-values, with pink representing higher values. Larger points represent higher pathway impact values. Analysis was performed with MetaboAnalyst 5.0 and the plot was produced using the R package ggplot2.

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