Table 2 Disease characteristics of cases with B-cell depletion therapy prior to COVID-19.

From: Effect of antecedent B-cell depletion therapy for patients hospitalized with COVID-19 within a single health system: a propensity score analysis

Characteristic

B-cell depleted patients (N = 50)

Indication for B-cell depletion therapy, no. (%)

 Benign hematological disordera

2 (4)

 Malignancyb

21 (42)

 Neurologic disorderc

9 (18)

 Rheumatologic disorderd

14 (28)

 Solid organ transplante

4 (8)

Type of B-cell depletion medication, no. (%)

 Rituximab

44 (88)

 Ocrelizumab

6 (12)

Most recent B-cell depletion medication prior to COVID-19 onset, no. (%)

 <  = 90 days

28 (56)

 91 days–365 days

16 (32)

 > 365 days

6 (12)

  1. aBenign hematologic disorder includes: acquired factor VIII inhibitor and immune thrombocytopenic purpura.
  2. bMalignancy includes: lymphoma, central nervous system lymphoma, mantle cell lymphoma, chronic lymphocytic leukemia, and Non-Hodgkin’s lymphoma.
  3. cNeurologic disorder includes: multiple sclerosis, transverse myelitis, myasthenia gravis, anti-NMDA receptor encephalitis.
  4. dRheumatologic disorder includes: dermatomyositis, neuromyelitis optica, rheumatoid arthritis, interstitial lung disease, vasculitis, granulomatosis with polyangiitis, Sjogren’s syndrome, anti-synthetase syndrome, pemphigus vulgaris.
  5. eSolid organ transplant includes: antibody-mediated rejection.