Fig. 3
From: Identification of functional rare coding variants in IGF-1 gene in humans with exceptional longevity
Root mean square deviation (RMSD) and root mean square fluctuation (RMSF) of protein Cα atoms with respect to the initial structure obtained from three independent runs. Results from three simulation runs of each system are plotted as mean ± SD. (A) RMSD of wild-type and mutant IGF-1–IGF-1R complexes; (B) RMSF of Cα atoms of IGF-1R protein in the wild-type and mutant IGF-1–IGF-1R complexes; (C) RMSF of Cα atoms of IGF-1 protein in the wild-type and mutant IGF-1–IGF-1R complexes. Loop and helical regions of each protomer of IGF-1R and IGF-1 binding regions that make contact with IGF-1R are identified with black bars.
