Fig. 5
From: Identification of functional rare coding variants in IGF-1 gene in humans with exceptional longevity
Binding interface of chain A and Chain B of IGF-1R. (A) Enlarged binding pose showing the residues that interact in the interface; (B) The percentage of simulation time during which intermolecular contacts were retained between chain A and chain B interacting residues of IGF-1R dimer. Results from three simulation runs of each system are plotted as mean ± SEM. For clarity, the IGF-1R domains are colored differently. The L1, L2, FnIII-1, are FnIII-2 domains of both chains are shown in green, yellow, blue, and grey color, respectively. Hydrogen bonds and salt bridges are represented by yellow and pink dotted lines, respectively. Interacting residues of chain A and chain B are shown in grey and orange sticks, respectively.
