Fig. 2

Development and validation of the NPM prognostic model. (A) ROC curve demonstrating the predictive performance of the NPM model compared to NP/LHb and Mono alone. The NPM model achieves the highest AUC, indicating superior prognostic accuracy. (B, C) Kaplan-Meier survival curves stratified by NPM score, showing significantly poorer OS in patients with higher NPM values (p < 0.001). (D) Stratified survival analysis indicating that high NPM scores correlate with increased mortality risk in CRC patients.