Table 1 Baseline clinicopathological characteristics of colorectal cancer patients in the training and validation cohorts.
Characteristic | Cohort | ||
|---|---|---|---|
Overall, N = 566 | Training cohort, N = 435 | Validation cohort, N = 131 | |
Gender | |||
Fermale | 232 (41.0%) | 182 (41.8%) | 50 (38.2%) |
Male | 334 (59.0%) | 253 (58.2%) | 81 (61.8%) |
Age | |||
< 45 years | 58 (10.2%) | 45 (10.3%) | 13 (9.9%) |
> 60 years | 312 (55.1%) | 248 (57.0%) | 64 (48.9%) |
45–60 years | 196 (34.6%) | 142 (32.6%) | 54 (41.2%) |
BMI | |||
< 18.5 | 13 (2.3%) | 12 (2.8%) | 1 (0.8%) |
≥ 28 | 67 (11.9%) | 52 (12.0%) | 15 (11.5%) |
18.5–24 | 253 (44.8%) | 190 (43.8%) | 63 (48.1%) |
24–28 | 232 (41.1%) | 180 (41.5%) | 52 (39.7%) |
Smoking | |||
No | 394 (69.6%) | 299 (68.7%) | 95 (72.5%) |
Yes | 172 (30.4%) | 136 (31.3%) | 36 (27.5%) |
Drink | |||
No | 457 (80.7%) | 355 (81.6%) | 102 (77.9%) |
Yes | 109 (19.3%) | 80 (18.4%) | 29 (22.1%) |
T stage | |||
T1 | 31 (5.5%) | 26 (6.0%) | 5 (3.8%) |
T2 | 90 (15.9%) | 72 (16.6%) | 18 (13.7%) |
T3 | 398 (70.3%) | 303 (69.7%) | 95 (72.5%) |
T4 | 47 (8.3%) | 34 (7.8%) | 13 (10.0%) |
N stage | |||
N0 | 363 (64.1%) | 278 (63.9%) | 85 (64.9%) |
N1 | 122 (21.6%) | 92 (21.1%) | 30 (22.9%) |
N2 | 81 (14.3%) | 65 (14.9%) | 16 (12.2%) |
TNM stage | |||
I | 107 (18.9%) | 87 (20.0%) | 20 (15.3%) |
II | 258 (45.6%) | 193 (44.4%) | 65 (49.6%) |
III | 192 (33.9%) | 149 (34.3%) | 43 (32.8%) |
IV | 9 (1.6%) | 6 (1.4%) | 3 (2.3%) |
Differentiation degree | |||
Moderately | 470 (83.0%) | 354 (81.4%) | 116 (88.5%) |
Poorly | 86 (15.2%) | 72 (16.6%) | 14 (10.7%) |
Well | 10 (1.8%) | 9 (2.1%) | 1 (0.8%) |
Nerve invasion | |||
Negative | 487 (86.0%) | 365 (83.9%) | 122 (93.1%) |
Positive | 79 (14.0%) | 70 (16.1%) | 9 (6.9%) |
Intravascular tumor emboli | |||
Negative | 457 (80.7%) | 357 (82.1%) | 100 (76.3%) |
Positive | 109 (19.3%) | 78 (17.9%) | 31 (23.7%) |
CEA | |||
High | 210 (37.1%) | 156 (35.9%) | 54 (41.2%) |
Normal | 356 (62.9%) | 279 (64.1%) | 77 (58.8%) |
CA-199 | |||
High | 57 (10.1%) | 48 (11.0%) | 9 (6.9%) |
Normal | 509 (89.9%) | 387 (89.0%) | 122 (93.1%) |
