Table 4 Univariate and multivariate Cox regression analysis of factors associated with overall survival in colorectal cancer patients.

From: Prognostic value of combined NP and LHb index with absolute monocyte count in colorectal cancer patients

Characteristic

Univariable

Multivariable

N

HR

95% CI

p-value

N

HR

95% CI

p-value

NPM

        

0

205

–

–

 

205

–

–

 

1

166

5.56

2.95,10.47

< 0.001

166

5.09

2.64, 9.80

< 0.001

2

64

13.56

7.03,26.17

< 0.001

63

10.82

5.26, 22.25

< 0.001

Gender

        

fermale

182

–

–

 

182

–

–

 

male

253

0.75

0.50,1.12

0.158

252

0.76

0.45,1.28

0.303

Age

        

< 45years

45

–

–

 

45

–

–

 

>60years

248

1.07

0.53, 2.17

0.845

248

1.34

0.62, 2.89

0.457

45–60 years

142

1.09

0.52, 2.29

0.821

141

1.32

0.59,2.98

0.497

BMI

        

< 18.5

12

–

–

 

12

–

–

 

≥ 28

52

0.92

0.26,3.22

0.894

52

1.03

0.28, 3.82

0.969

18.5–24

190

0.87

0.27, 2.79

0.810

190

0.99

0.29, 3.35

0.991

24–28

180

0.64

0.20,2.10

0.466

180

0.86

0.25,2.96

0.807

Smoking

        

No

299

–

–

 

299

–

–

 

Yes

136

0.70

0.44, 1.11

0.128

135

0.80

0.40, 1.58

0.521

Drink

        

No

355

–

–

 

355

–

–

 

Yes

80

0.85

0.49,1.45

0.545

79

1.43

0.69, 2.98

0.338

T stage

        

T1

26

–

–

 

26

–

–

 

T2

72

1.85

0.22,15.82

0.575

72

1.23

0.14,10.80

0.855

T3

303

7.08

0.98, 50.95

0.052

303

2.87

0.25,33.55

0.401

T4

34

16.14

2.14,121.72

0.007

33

3.96

0.32,49.46

0.285

N stage

        

N0

278

–

–

 

278

–

–

 

N1

92

2.14

1.29, 3.55

0.003

91

0.23

0.07,0.82

0.023

N2

65

4.48

2.75, 7.31

< 0.001

65

0.53

0.15,1.83

< 0.001

TNM stage

        

I

87

–

–

 

87

–

–

 

II

193

2.25

0.94,5.43

0.070

193

0.76

0.16,3.54

0.724

III

149

6.50

2.80, 15.10

< 0.001

148

5.79

0.89, 37.67

0.066

IV

6

26.27

7.96, 86.70

< 0.001

6

4.52

0.62, 32.91

0.137

Differentiation degree

        

Well

9

–

–

 

9

–

–

 

Moderately

354

1.96

0.27,14.07

0.505

354

1.52

0.20,11.56

0.687

Poorly

72

2.51

0.34, 18.72

0.371

71

1.54

0.20,12.06

0.679

Nerve invasion

        

Negative

365

–

–

 

365

–

–

 

Positive

70

1.40

0.85, 2.31

0.191

69

1.37

0.72, 2.59

0.341

Intravascular tumo remboli (%)

        

Negative

357

–

–

 

356

–

–

 

Positive

78

1.38

0.85,2.25

0.189

78

1.04

0.57,1.88

0.909

CEA

        

Normal

279

–

–

 

279

–

–

 

High

156

1.59

1.07, 2.39

0.023

155

1.22

0.78, 1.89

0.389

CA-199

        

Normal

387

–

–

 

386

–

–

 

High

48

2.19

1.32, 3.62

0.002

48

1.23

0.70, 2.16

0.477

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