Fig. 1 | Scientific Reports

Fig. 1

From: Viral mediated α-synuclein overexpression results in greater transgene levels and α-synuclein overload in mice bearing kinase dead mutation of LRRK2

Fig. 1

LRRK2 KD mice injected with AAV-h-A53Tα-syn show mild motor deficits. Stepping activity was evaluated in 12-month-old WT and LRRK2 KD mice injected with AAV-h-A53Tα-syn or AAV-GFP using the drag test. Motor tests were carried out before (baseline, time 0) and 1, 2, 3 months after surgery. Data are expressed as number of steps and are mean ± SEM of 9 mice per group. *p < 0.05 (three-way ANOVA followed by Tukey’s test for multiple comparisons).

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