Fig. 2 | Scientific Reports

Fig. 2

From: Viral mediated α-synuclein overexpression results in greater transgene levels and α-synuclein overload in mice bearing kinase dead mutation of LRRK2

Fig. 2

AAV-h-A53Tα-syn injection results in greater transgene levels in LRRK2 KD mice compared to WT mice. h-A53Tα-syn transgene expression was evaluated by immunohistochemistry in 12-month-old WT and LRRK2 KD mice 3 months after AAV-h-A53Tα-syn or AAV-GFP injection. Representative images and quantification of h-A53Tα-syn in SNpc (A) and striatum (B). Data are expressed as mean percentage ± SEM of: panel (A), n = 9 mice (KD AAV-h-A53Tα-syn, KD AAV-GFP, WT AAV-h-A53Tα-syn) or 10 mice (WT AAV-GFP) per group; panel (B), n = 9 mice per group. **p < 0.01 (ART ANOVA followed by the Bonferroni’s test for multiple comparisons).

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