Fig. 5 | Scientific Reports

Fig. 5

From: Viral mediated α-synuclein overexpression results in greater transgene levels and α-synuclein overload in mice bearing kinase dead mutation of LRRK2

Fig. 5

AAV-h-A53Tα-syn injection does not result in degeneration of the nigrostriatal dopaminergic pathway. Stereological count of nigral neurons and optical density of striatal TH + terminals were carried out in 12-month-old WT and LRRK2 KD mice 3 months after AAV-h-A53Tα-syn or AAV-GFP injection. Representative images and quantification of TH+ neurons in SNpc (A) and terminals in striatum (in grey scale arbitrary units; B). Data are expressed as mean percentage ± SEM of n = 6 mice per group (A) or n = 9 mice per group (B).

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