Table 1 Baseline characteristics of patients classified by HGI-RDW levels.

From: Combined glycated hemoglobin index and red cell distribution width predict in-hospital mortality in critically ill sepsis patients based on MIMIC-IV analysis

 

Level

Overall

Q1

Q2

Q3

Q4

P-value

Number

 

13,726

3699

3166

3351

3510

 

HGI level (%)

Low

6865 (50.01)

3699 (100.00)

3166 (100.00)

0 (0.00)

0 (0.00)

< 0.0001

 

High

6861 (49.99)

0 (0.00)

0 (0.00)

3351 (100.00)

3510 (100.00)

 

RDW level (%)

Low

7050 (51.36)

3699 (100.00)

0 (0.00)

3351 (100.00)

0 (0.00)

< 0.0001

 

High

6676 (48.64)

0 (0.00)

3166 (100.00)

0 (0.00)

3510 (100.00)

 

Age (%)

> 65

7914 (57.66)

1948 (52.66)

1755 (55.43)

1996 (59.56)

2215 (63.11)

< 0.0001

 

≤ 65

5812 (42.34)

1751 (47.34)

1411 (44.57)

1355 (40.44)

1295 (36.89)

 

Gender (%)

F

5413 (39.44)

1347 (36.42)

1339 (42.29)

1177 (35.12)

1550 (44.16)

< 0.0001

 

M

8313 (60.56)

2352 (63.58)

1827 (57.71)

2174 (64.88)

1960 (55.84)

 

Race (%)

Black

1671 (12.17)

246 (6.65)

401 (12.67)

418 (12.47)

606 (17.26)

< 0.0001

 

Others

3068 (22.35)

843 (22.79)

668 (21.10)

790 (23.58)

767 (21.85)

 
 

White

8987 (65.47)

2610 (70.56)

2097 (66.23)

2143 (63.95)

2137 (60.88)

 

Marital status (%)

Divorced

1028 (7.49)

233 (6.30)

251 (7.93)

265 (7.91)

279 (7.95)

< 0.0001

 

Married

6560 (47.79)

1899 (51.34)

1374 (43.40)

1705 (50.88)

1582 (45.07)

 
 

Others

939 (6.84)

306 (8.27)

243 (7.68)

199 (5.94)

191 (5.44)

 
 

Single

3610 (26.30)

899 (24.30)

924 (29.19)

787 (23.49)

1000 (28.49)

 
 

Widowed

1589 (11.58)

362 (9.79)

374 (11.81)

395 (11.79)

458 (13.05)

 

INR (median [IQR])

 

1.200 [1.100, 1.500]

1.200 [1.100, 1.400]

1.300 [1.100, 1.600]

1.200 [1.100, 1.400]

1.300 [1.100, 1.600]

< 0.0001

PT (median [IQR])

 

13.600 [12.200, 16.300]

13.200 [11.900, 15.200]

14.400 [12.600, 18.000]

13.100 [11.900, 15.100]

14.000 [12.400, 17.400]

< 0.0001

PTT (median [IQR])

 

31.700 [27.900, 41.400]

30.600 [27.500, 37.000]

33.400 [28.700, 46.475]

30.800 [27.300, 37.800]

32.900 [28.400, 45.400]

< 0.0001

Heart rate (median [IQR])

 

83.440 [74.719, 94.183]

82.155 [74.000, 92.000]

84.846 [75.423, 97.100]

83.322 [75.163, 93.000]

84.000 [74.585, 95.080]

< 0.0001

SBP (median [IQR])

 

114.167 [106.036, 125.255]

113.952 [106.320, 124.000]

112.719 [104.278, 124.429]

115.583 [107.654, 126.294]

114.219 [105.652, 126.735]

< 0.0001

DBP (median [IQR])

 

60.758 [54.836, 67.726]

61.717 [56.090, 68.505]

61.029 [54.714, 67.956]

60.222 [54.800, 67.091]

59.917 [53.783, 67.327]

< 0.0001

MBP (median [IQR])

 

76.143 [70.750, 83.200]

76.926 [72.000, 83.918]

75.963 [70.250, 83.196]

75.981 [71.000, 82.920]

75.342 [69.624, 82.750]

< 0.0001

SPO2 (median [IQR])

 

97.297 [95.887, 98.526]

97.458 [96.115, 98.577]

97.276 [95.750, 98.561]

97.269 [95.920, 98.493]

97.185 [95.783, 98.481]

0.0001

Hemoglobin (median [IQR])

 

10.300 [8.800, 12.100]

11.400 [9.800, 13.000]

9.300 [8.100, 10.800]

11.100 [9.600, 12.700]

9.600 [8.325, 11.000]

< 0.0001

Hematocrit (median [IQR])

 

31.500 [27.300, 36.700]

34.200 [29.500, 39.100]

29.000 [25.500, 33.400]

33.600 [29.100, 38.300]

29.850 [26.400, 34.200]

< 0.0001

MCV (median [IQR])

 

91.000 [87.000, 96.000]

92.000 [89.000, 96.000]

92.000 [87.000, 97.000]

91.000 [88.000, 95.000]

90.000 [85.000, 95.000]

< 0.0001

MCH (median [IQR])

 

30.000 [28.400, 31.400]

30.700 [29.500, 31.900]

29.800 [27.925, 31.400]

30.200 [28.900, 31.400]

28.800 [26.900, 30.500]

< 0.0001

Temperature (median [IQR])

 

36.830 [36.596, 37.122]

36.857 [36.620, 37.136]

36.814 [36.590, 37.112]

36.843 [36.616, 37.144]

36.796 [36.559, 37.093]

< 0.0001

RBC (median [IQR])

 

3.480 [2.982, 4.080]

3.700 [3.180, 4.260]

3.150 [2.730, 3.700]

3.690 [3.190, 4.240]

3.350 [2.920, 3.890]

< 0.0001

WBC (median [IQR])

 

9.000 [6.600, 12.400]

8.900 [6.600, 12.000]

9.000 [6.200, 13.000]

9.000 [6.800, 12.100]

9.100 [6.500, 12.600]

0.4522

eGFR (median [IQR])

 

33.133 [0.000, 58.959]

45.979 [0.000, 65.053]

23.320 [0.000, 56.956]

40.174 [0.000, 60.316]

15.569 [0.000, 50.295]

< 0.0001

APSIII (median [IQR])

 

44.000 [32.000, 59.000]

37.000 [27.000, 51.000]

47.000 [36.000, 62.000]

42.000 [32.000, 56.000]

49.000 [37.000, 64.000]

< 0.0001

SAPSII (median [IQR])

 

37.000 [30.000, 46.000]

35.000 [28.000, 43.000]

39.000 [31.000, 49.000]

36.000 [30.000, 45.000]

40.000 [32.000, 49.000]

< 0.0001

SIRS (median [IQR])

 

3.000 [2.000, 3.000]

3.000 [2.000, 3.000]

3.000 [2.000, 3.000]

3.000 [2.000, 3.000]

3.000 [2.000, 3.000]

0.0836

SOFA (median [IQR])

 

5.000 [3.000, 7.000]

5.000 [3.000, 7.000]

6.000 [3.000, 9.000]

4.000 [3.000, 7.000]

5.000 [3.000, 8.000]

< 0.0001

Antibiotic (%)

Beta-lactams

1445 (10.53)

313 (8.46)

385 (12.16)

326 (9.73)

421 (11.99)

< 0.0001

 

Glycopeptides

3410 (24.84)

816 (22.06)

818 (25.84)

850 (25.37)

926 (26.38)

 
 

Macrolides

482 (3.51)

113 (3.05)

123 (3.89)

109 (3.25)

137 (3.90)

 
 

Others

8389 (61.12)

2457 (66.42)

1840 (58.12)

2066 (61.65)

2026 (57.72)

 

Myocardial infarction (%)

No

11,162 (81.32)

3149 (85.13)

2610 (82.44)

2622 (78.25)

2781 (79.23)

< 0.0001

 

Yes

2564 (18.68)

550 (14.87)

556 (17.56)

729 (21.75)

729 (20.77)

 

Cerebrovascular disease (%)

No

11,402 (83.07)

3001 (81.13)

2641 (83.42)

2787 (83.17)

2973 (84.70)

0.0008

 

Yes

2324 (16.93)

698 (18.87)

525 (16.58)

564 (16.83)

537 (15.30)

 

CPD (%)

No

10,482 (76.37)

2967 (80.21)

2375 (75.02)

2634 (78.60)

2506 (71.40)

< 0.0001

 

Yes

3244 (23.63)

732 (19.79)

791 (24.98)

717 (21.40)

1004 (28.60)

 

CHF (%)

No

9508 (69.27)

2972 (80.35)

2117 (66.87)

2438 (72.75)

1981 (56.44)

< 0.0001

 

Yes

4218 (30.73)

727 (19.65)

1049 (33.13)

913 (27.25)

1529 (43.56)

 

Severe liver disease (%)

No

13,099 (95.43)

3630 (98.13)

2814 (88.88)

3317 (98.99)

3338 (95.10)

< 0.0001

 

Yes

627 (4.57)

69 (1.87)

352 (11.12)

34 (1.01)

172 (4.90)

 

Diabetes (%)

No

9529 (69.42)

3318 (89.70)

2642 (83.45)

1711 (51.06)

1858 (52.93)

< 0.0001

 

Yes

4197 (30.58)

381 (10.30)

524 (16.55)

1640 (48.94)

1652 (47.07)

 

Hypertension (%)

No

4967 (36.19)

1352 (36.55)

1378 (43.52)

974 (29.07)

1263 (35.98)

< 0.0001

 

Yes

8759 (63.81)

2347 (63.45)

1788 (56.48)

2377 (70.93)

2247 (64.02)

 
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