Fig. 14
From: In vitro enzymatic and cell culture assays for SARS-CoV-2 main protease interaction with ambenonium
SASA Analysis of active site, dimer and monomer forms. SASA analysis of the active site shows that the dimer (blue) has consistently lower SASA values (~ 800–1000 Å2) compared to the monomer (orange, ~ 1200–1400 Å2). This indicates reduced solvent exposure in the dimeric form, likely due to structural compactness or intersubunit interactions, highlighting the impact of oligomerization on active site accessibility.
