Table 4 The association between total urinary arsenic level, blood lead and cadmium levels and clear cell RCC.

From: Interaction of tissue inhibitor of metalloproteinase 3 gene polymorphism, blood cadmium and total urinary arsenic levels on clear cell renal cell carcinoma

Variables

Clear cell RCC cases

(N = 281)

Controls

(N = 689)

Age-sex adjusted ORs (95% CI)

Multivariate ORs

(95% CI)

Total urinary arsenic concentration (µg/L)

12.28 (5.53, 22.52)a, ***

17.22 (9.44, 29.79) a, ***

  

≤ 11.89

136 (48.40)

230 (33.38)

1.00b, §.**

1.00c, §,*

11.89–25.04

86 (30.60)

230 (33.38)

1.47 (1.00–2.17)*

1.51 (0.99–2.30)+

> 25.04

59 (21.00)

229 (33.24)

1.85 (1.15–2.96)*

1.87 (1.11–3.16)*

Total urinary arsenic concentration

(µg/g creatinine)

17.08 (10.61, 26.87) a, **

14.92 (9.76, 23.96) a, **

  

≤ 11.22

78 (27.76)

230 (33.38)

1.00§,**

1.00d, §,**

11.22–20.14

89 (31.67)

230 (33.38)

1.20 (0.84–1.72)

1.39 (0.94–2.05)

> 20.14

114 (44.57)

229 (33.24)

1.65 (1.16–2.37)**

1.72 (1.16–2.56)**

Blood lead level

(µg/dL)

44.73 (33.62, 62.92)

46.32 (30.78, 67.14)

  

≤ 36.14

49 (32.67)

224 (33.38)

1.00

1.00d

36.14–58.54

57 (38.00)

224 (33.38)

1.17 (0.77–1.79)

1.63 (1.02–2.60)*

> 58.54

44 (29.33)

223 (33.24)

0.89 (0.57–1.40)

1.16 (0.70–1.90)

Blood cadmium level

(µg/L)

1.85 (1.16, 2.96)***

1.26 (0.78, 2.00) ***

  

≤ 0.92

24 (16.00)

229 (34.13)

1.00§,***

1.00d, §,***

0.92–1.64

40 (26.67)

220 (32.79)

1.84 (1.07–3.17)*

2.36 (1.31–4.24)**

> 1.64

86 (57.33)

222 (33.08)

3.99 (2.43–6.57)***

5.41 (3.06–9.55)***

  1. Values expressed as median (first quartile, third quartile) or number (percent).
  2. One hundred and thirty one participants were missing for blood cadmium and lead concentration.
  3. aWilcoxon rank-sum test.
  4. bAdjusted for age, sex, and urinary creatinine level.
  5. cAdjusted for age; sex; creatinine level; cumulative cigarette smoking; educational level; alcohol, coffee, and tea consumption; analgesic usage; diabetes; and hypertension.
  6. dAdjusted for age; sex; cumulative cigarette smoking; educational level; alcohol, coffee, and tea consumption; analgesic usage; diabetes; and hypertension.
  7. *p < 0.05, **p < 0.01, ***p < 0.001.
  8. § Trend test.