Fig. 8 | Scientific Reports

Fig. 8

From: Network pharmacology-based investigation of the pharmacological mechanisms of diosgenin in nonalcoholic steatohepatitis

Fig. 8

Diosgenin reduces cellular triglyceride deposition and attenuates FFA-induced inflammation. (A) Cellular Oil Red O staining (× 40) of HepG2 cells treated with FFA and different concentrations of diosgenin. (B) Determination of cellular triglyceride (TG) levels in HepG2 cells treated with FFA and different concentrations of diosgenin; (C) Determination of cellular total cholesterol (TC) and free cholesterol (FC) levels in HepG2 cells treated with FFA and different concentrations of diosgenin; (D) Determination of IL-6 levels in cell culture supernatants in HepG2 cells treated with FFA and different concentrations of diosgenin; (D) Determination of IL-6 in cell culture supernatant after treatment of HepG2 cells with FFA and different concentrations of diosgenin. The data are expressed as the mean ± standard deviation; * indicates P < 0.05, ** indicates P < 0.01, *** indicates P < 0.001, and **** indicates P < 0.0001.

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