Table 2 Relationship between thrombocytosis and S-Klotho (pg/mL) in 3 models.

	n.total	n.event_%	Crude	p-value	Model1	p-value	Model2	p-value	Model3	p-value	Model4	p-value
Klotho (pg/ml)
Q1	4232	40 (0.9)	1 (Ref)		1 (Ref)		1 (Ref)		1 (Ref)		1 (Ref)
Q2	4234	24 (0.6)	0.6 (0.36–0.99)	0.047	0.57 (0.34–0.95)	0.032	0.58 (0.34–0.99)	0.046	0.61 (0.35–1.05)	0.073	0.6 (0.36–1.01)	0.055
Q3	4234	22 (0.5)	0.55 (0.32–0.92)	0.024	0.51 (0.3–0.87)	0.013	0.51 (0.3–0.88)	0.016	0.56 (0.32–0.98)	0.04	0.49 (0.29–0.84)	0.01
Trend.test	12,700	86 (0.7)		0.018		0.009		0.013		0.033		0.008
Per Klotho increase (100 pg/mL)	12,700	86 (0.7)	0.91 (0.84–0.99)	0.025	0.9 (0.83–0.98)	0.014	0.9 (0.83–0.98)	0.019	0.91 (0.84–1)	0.04	0.89 (0.82–0.97)	0.007

OR, odds ratio; CI, confidence interval; Ref: reference.
Model 1 was adjusted for Age.
Model 2 was adjusted for sociodemographic (age, sex, marital status, race/ethnicity, education level, family income).
Model 3 was adjusted for sociodemographic (age, sex, marital status, race/ethnicity, education level, family income), smoking status, hypertension, diabetes, CVD, stroke, coronary heart disease, body mass index, and congestive heart failure.
Model 4 was adjusted for sociodemographic (age, sex, marital status, race/ethnicity, education level, family income), smoking status, hypertension, diabetes, CVD, stroke, coronary heart disease, body mass index, congestive heart failure, albumin, creatinine, phosphorus, 25(OH)D2 and 25(OH)D3.

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