Table 5 Univariate and multivariate analyses of survival for the ineligible group (n = 84).
From: Prognostic impact of clinical trial eligibility in patients with advanced gastric cancer
Independent factor | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
Hazard ratio | 95% CI | P value | Hazard ratio | 95% CI | P value | |
Sex, female | 0.67 | 0.43–1.06 | 0.09 | |||
Age, ≥ 68 years | 1.24 | 0.78–1.97 | 0.37 | |||
Performance status, 2–3 | 3.26 | 2.02–5.24 | < 0.01 | 2.90 | 1.77–4.74 | < 0.01 |
Tumor location, middle/lower | 0.71 | 0.44–1.14 | 0.15 | |||
Macroscopic type, type 4 | 1.03 | 0.65–1.65 | 0.90 | |||
Number of distant metastatic sites, ≥ 2 | 1.85 | 1.08–3.17 | 0.03 | 1.27 | 0.73–2.21 | 0.40 |
Liver metastasis, presence | 0.88 | 0.49–1.58 | 0.66 | |||
Distant lymph node metastasis, presence | 1.49 | 0.89–2.49 | 0.13 | |||
Peritoneal dissemination, presence | 1.35 | 0.80–2.28 | 0.26 | |||
Bone metastasis, presence | 1.45 | 0.45–4.64 | 0.53 | |||
Histological type, undifferentiated | 1.18 | 0.67–2.08 | 0.57 | |||
First-line regimen of chemotherapy, S-1 alone | 3.71 | 0.85–16.28 | 0.08 | |||
First-line regimen of chemotherapy, platinum-based | 1.17 | 0.74–1.87 | 0.50 | |||
Disease control, PD | 4.76 | 2.78–8.17 | < 0.01 | 4.11 | 2.35–7.19 | < 0.01 |
Conversion surgery, presence | 0.14 | 0.06–0.33 | < 0.01 | 0.20 | 0.08–0.49 | < 0.01 |