Table 5 Univariate and multivariate analyses of survival for the ineligible group (n = 84).

From: Prognostic impact of clinical trial eligibility in patients with advanced gastric cancer

Independent factor

Univariate analysis

Multivariate analysis

Hazard ratio

95% CI

P value

Hazard ratio

95% CI

P value

Sex, female

0.67

0.43–1.06

0.09

   

Age, 68 years

1.24

0.78–1.97

0.37

   

Performance status, 2–3

3.26

2.02–5.24

< 0.01

2.90

1.77–4.74

< 0.01

Tumor location, middle/lower

0.71

0.44–1.14

0.15

   

Macroscopic type, type 4

1.03

0.65–1.65

0.90

   

Number of distant metastatic sites, 2

1.85

1.08–3.17

0.03

1.27

0.73–2.21

0.40

Liver metastasis, presence

0.88

0.49–1.58

0.66

   

Distant lymph node metastasis, presence

1.49

0.89–2.49

0.13

   

Peritoneal dissemination, presence

1.35

0.80–2.28

0.26

   

Bone metastasis, presence

1.45

0.45–4.64

0.53

   

Histological type, undifferentiated

1.18

0.67–2.08

0.57

   

First-line regimen of chemotherapy, S-1 alone

3.71

0.85–16.28

0.08

   

First-line regimen of chemotherapy, platinum-based

1.17

0.74–1.87

0.50

   

Disease control, PD

4.76

2.78–8.17

< 0.01

4.11

2.35–7.19

< 0.01

Conversion surgery, presence

0.14

0.06–0.33

< 0.01

0.20

0.08–0.49

< 0.01

  1. CI confidence interval, PD progressive disease