Table 1 Characteristics of included CIS patients with high-risk PFO and without PFO.

From: Oral microbiome dysbiosis in cryptogenic ischemic stroke patients with high-risk patent foramen ovale

 

Patients with high-risk PFO (n = 52)

Patients without PFO (n = 52)

p-value

Gender

Male

36 (69.2)

29 (55.8)

0.158

Female

16 (30.8)

23 (44.2)

 

Mean age (SD), years

 

41.01 (6.5)

36.98 (9.2)

0.040

BMI (SD), kg/m2

 

26.8 (4.1)

26.3 (4.4)

0.266

Smoking ever

Yes

21 (40.4)

30 (57.7)

0.079

No

31 (59.6)

22 (42.3)

 

Heavy alcohol use

Yes

7 (13.5)

22 (42.3)

0.001

No

45 (86.5)

30 (57.7)

 

Abdominal obesity

Yes

25 (48.1)

25 (48.1)

1.000

No

27 (51.9)

27 (51.9)

 

Hypertension

Yes

2 (3.8)

17 (32.7)

 < 0.001

No

50 (96.2)

35 (67.3)

 

Antibiotics (preceding 3 months)

Yes

9 (17.3)

5 (9.6)

0.253

No

43 (82.7)

47 (90.4)

 

Caries

Yes

21 (40.4)

29 (55.8)

0.118

No

31 (59.6)

23 (44.2)

 

Periodontitis#

Yes

11 (21.2)

17 (32.7)

0.206

No

39 (75)

34 (65.4)

 

Mucosal lesions and changes*

Yes

13 (25)

7 (13.5)

0.150

No

39 (75)

44 (84.6)

 

Regular dentist check-ups

Yes

27 (51.9)

26 (50.0)

0.924

No

25 (48.1)

25 (48.1)

 

Bleeding on probing, mean (SD)

 

41.1 (14.9)

43.1 (14.4)

0.742

Number of missing teeth

   

0.952

 0

 

36 (69.2)

 36 (69.2)

 

 1–2

 

6 (11.5)

 7 (13.5)

 

 3–5

 

9 (17.3)

 8 (15.4)

 

  > 5

 

1 (1.9)

 1 (1.9)

 

Stroke severity on admission, NIHSS score*

   

0.413

 No symptoms

 

13 (25)

 14 (26.9)

 

 Mild

 

32 (61.5)

 24 (46.2)

 

 Moderate

 

6 (11.5)

 12 (23.1)

 

 Severe

 

1 (1.9)

 2 (3.8)

 
  1. BMI, Body mass index; SD, standard deviation; Abdominal obesity; men ≥ 0.9, women ≥ 0.85; *NIHSS score: 0 (no scorable symptoms on admission), 1–4 (mild symptoms), 5–9 (moderate symptoms), and ≥ 10 (severe symptoms). Missing data: #periodontitis n = 3, regular dentist check-ups n = 1, * Mucosal lesions and changes n = 1.
  2. Significant values are in bold.