Table 3 Determination of cryoprotectant effect and storage conditions – study results.

From: Development of donepezil hydrochloride-loaded PLGA-based nanoparticles for Alzheimer’s disease treatment

Code

PS, nm

(mean ± SD)

PDI

(mean ± SD)

ZP, mV

(mean ± SD)

Fresh formulation

132.40 ± 4.59

0.156 ± 0.008

-20.60 ± 0.69

200 µL trehalose solution

165.33 ± 6.83

0.189 ± 0.024

-23.17 ± 1.75

300 µL trehalose solution

163.77 ± 0.97

0.246 ± 0.006

-20.17 ± 1.19

500 µL trehalose solution

152.67 ± 1.16

0.113 ± 0.018

-18.23 ± 1.37

600 µL trehalose solution

136.90 ± 2.74

0.106 ± 0.004

-23.07 ± 1.67

800 µL trehalose solution

135.53 ± 1.25

0.125 ± 0.033

-21.93 ± 2.10

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