Table 4 Short-term gastrointestinal stability assessment study results.

From: Development of donepezil hydrochloride-loaded PLGA-based nanoparticles for Alzheimer’s disease treatment

Hours

PS (nm, mean ± SD)

pH 1.2

pH 6.8

pH 7.4

distilled water

1

142.6 ± 0.4

211.4 ± 5.0

192.0 ± 3.5

177.0 ± 5.0

2

178.1 ± 2.7

207.0 ± 1.4

209.5 ± 4.7

193.7 ± 4.7

3

189.4 ± 17.5

207.7 ± 4.2

212.9 ± 4.4

190.5 ± 5.5

4

285.1 ± 5.6

192.0 ± 13.2

214.5 ± 4.1

219.6 ± 0.8

5

393.4 ± 13.7

206.6 ± 2.8

213.7 ± 2.0

218.5 ± 2.1

6

481.2 ± 5.8

208.7 ± 0.9

209.2 ± 3.5

207.6 ± 2.7

7

521.0 ± 16.6

220.3 ± 11.4

224.5 ± 5.4

220.0 ± 3.7

24

514.8 ± 20.3

218.9 ± 2.5

198.1 ± 4.1

218.1 ± 2.2

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