Table 3 Performance of different screening protocols in detecting liver cancer in total population or in subpopulations stratified by aMAP score.
Screening method | Se (95%CI) | Sp (95%CI) | PPV (95%CI) | NPV (95%CI) | AUC (95%CI) | Categorical NRI (95%CI) |
|---|---|---|---|---|---|---|
Total | ||||||
AFP/US | 70.8 (60.2–79.9) | 96.4 (95.6–97.1) | 41.2 (33.3–49.4) | 98.9 (98.5–99.3) | 0.836 (0.821–0.850) | Ref. |
GALADUS | 91.0 (83.1–96.0) | 95.9 (95.1–96.6) | 44 (36.7–51.5) | 99.7 (99.3–99.9) | 0.935& (0.924–0.944) | 0.197@ (0.113–0.281) |
aMAP < 60 | ||||||
AFP/US | 75.0 (50.9–91.3) | 96.7 (95.8–97.4) | 19.0 (11.0-29.4) | 99.7 (99.4–99.9) | 0.858 (0.842–0.874) | Ref. |
GALADUS | 80.0 (56.3–94.3) | 97.6 (96.8–98.2) | 25.8 (15.5–38.5) | 99.8 (99.5–99.9) | 0.888 (0.873–0.902) | 0.059 (-0.036-0.155) |
aMAP ≥ 60 | ||||||
AFP/US | 69.6 (57.3–80.1) | 95.7 (93.7–97.1) | 64.9 (52.9–75.6) | 96.5 (94.6–97.8) | 0.826 (0.795–0.854) | Ref. |
GALADUS | 94.2 (85.8–98.4) | 90.5 (87.8–92.7) | 53.3 (44.0-62.4) | 99.3 (98.1–99.8) | 0.923& (0.900-0.942) | 0.195@ (0.091–0.298) |
aMAP triage$ | 89.9 (81.7–95.3) | 95.2 (94.3–96.0) | 39.8 (33.0-46.9) | 99.6 (99.3–99.8) | 0.925* (0.915–0.935) | 0.179# (0.097–0.261) |
