Table 3 Annual percentage change of overall antidepressants and by class of medication.

From: Trend analysis of antidepressant consumption in Italy from 2008 to 2022 in a public health perspective

Class of

medication

Lower

year

Upper

year

APC

LCI

UCI

p value

Overall

antidepressants

2008

2011

+ 4.77

3.68

5.88

< 0.0001

2011

2016

+ 0.80

– 0.12

1.37

0.08

2016

2022

+ 2.37

2.00

3.29

< 0.0001

SSRIs

2008

2013

+ 2.59

2.17

3.10

< 0.0001

2013

2017

– 0.23

0.98

0.36

0.36

2017

2022

+ 1.71

1.34

2.39

< 0.0001

SNRIs

2013

2017

+ 1.15

0.47

1.59

0.007

2017

2022

+ 2.94

2.61

3.42

< 0.0001

TCAs

2008

2019

– 1.46

– 2.07

– 0.65

< 0.0001

  1. Significant values are in [bold].
  2. SSRIs, selective serotonin reuptake inhibitors. SNRIs, serotonin and norepinephrine reuptake inhibitors. TCAs, tricyclic antidepressants. APC, Annual Percentage Change. LCI, lower confidence interval. UCI, upper confidence interval.
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