Fig. 4 | Scientific Reports

Fig. 4

From: Identification of pyroptosis-associated gene to predict fibrosis and reveal immune characterization in non-alcoholic fatty liver disease

Fig. 4

Identification of differentially expressed PRGs and fibrosis stage related PRGs (A) Heatmap of 23 differentially expressed PRGs in individual samples. The colorbar indicates normalized gene expression level. Red represents higher values, and blue represents lower values. (B) PPI network of differentially expressed PRGs, top 10 Hub genes of interaction were identified using Cytohubba. Node colors represent the interaction degree, redder colors indicate higher interaction scores, bluer colors indicate lower interaction scores. (C–G) Hepatic transcriptomic profiling of PRGs and liver fibrosis (C) BAX, (D) BAK1, (E) PYCARD, (F) NLRP3, (G) NLRP6. Kruskal–Wallis test were conducted for overall differences and Dunn’s Test with Benjamini–Hochberg correction for pairwise comparisons, *P < 0.05, **P < 0.01, ***P < 0.001.

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