Fig. 5

Protein–protein interaction analysis and overrepresentation enrichment analysis of the significant proteins. The String online tool was used to gain insights into the interactions and functions of these proteins. Each node is representative of a protein. Red node = extracellular region, purple node = extracellular space, green node = secreted, white node = second shell of interactors, filled node = 3D structure is known or predicted, empty node = unknown 3D structures. Each line represents protein–protein interactions. Light blue and pink interactions refer to known interactions (from databases or experiments). Green, red, and dark blue interactions refer to predicted interactions (gene neighborhood, fusions, and co-occurrence). Yellow line = text mining, black line = co-expression, light purple line = protein homology.