Table 2 Multivariable logistic regression analysis.

From: Comparison between norepinephrine plus epinephrine and norepinephrine plus vasopressin after return of spontaneous circulation in patients with out-of-hospital cardiac arrest

 

aOR

95% CI

p-value

Survival to discharge (reference = Norepinephrine + Epinephrine)

 Model 1

0.467

0.306–0.713

 < 0.001

 Model 2

0.564

0.363–0.876

0.011

 Model 3

0.574

0.364–0.905

0.017

 Model 4

0.454

0.277–0.746

0.002

Good neurological outcome (reference = Norepinephrine + Epinephrine)

 Model 1

0.319

0.166–0.612

0.001

 Model 2

0.421

0.207–0.857

0.017

 Model 3

0.449

0.214–0.941

0.034

 Model 4

0.346

0.150–0.794

0.012

Survival at 6 month* (reference = Norepinephrine + Epinephrine)

 Model 1

0.179

0.074–0.432

 < 0.001

 Model 2

0.239

0.095–0.598

0.002

 Model 3

0.233

0.088–0.619

0.004

 Model 4

0.145

0.048–0.443

0.001

Good neurological outcome at 6 month** (reference = Norepinephrine + Epinephrine)

 Model 1

0.139

0.044–0.436

0.001

 Model 2

0.192

0.058–0.635

0.007

 Model 3

0.231

0.065–0.818

0.023

 Model 4

0.218

0.048–0.987

0.048

  1. Model 1: age, sex, and calendar year were adjusted.
  2. Model 2: variables used in Model 1, comorbidities, and prehospital variables were adjusted.
  3. Model 3: variables used in Model 2, total epinephrine dose, CPR time, and lactate levels were adjusted.
  4. Model 4: variables used in Model 3, CAG, PCI, TTM, and ECMO were adjusted.
  5. *N = 834 (N = 359 in Norepinephrine + Epinephrine group and N = 475 in Norepinephrine + Vasopressin group).
  6. **N = 829 (N = 355 in Norepinephrine + Epinephrine group and N = 474 in Norepinephrine + Vasopressin group).
  7. Hosmer–Lemeshow test: p > 0.05 in all models.
  8. aOR adjusted odds ratio, CI confidence interval, CAG coronary angiography, PCI percutaneous coronary intervention, TTM targeted temperature management, ECMO extracorporeal membrane oxygenation.
Back to article page