Fig. 4

Heat map of chromosome copy-number changes in a recurrent sample from an adenoma patient after resection. The yellow color indicates copy-number gain, and blue indicates copy-number loss. Group 1 represents the presence of CIN in the first resected adenoma sample and the presence of CIN in the recurrent adenocarcinoma sample. Group 2 represents the absence of CIN in the first resected adenoma and the presence of CIN in the recurrent adenocarcinoma. Group 3 represents the absence of CIN in the first resected adenoma and the absence of CIN in the recurrent adenocarcinoma (which was not detected in this study). Group 4 represents the presence of CIN in the first resection of the adenoma and the absence of carcinoma in the recurrence. Group 5 represents the first resection of the adenoma without CIN and no carcinoma in the recurrence.