Fig. 6 | Scientific Reports

Fig. 6

From: Tumor associated chromosomal instability drives colorectal adenoma to adenocarcinoma progression based on 17 year follow up evidence

Fig. 6The alternative text for this image may have been generated using AI.

Copy-number variation in the MFN2 gene is a risk factor for adenocarcinogenesis. (A, B) Cvfit and lambda curves showing the least absolute shrinkage and selection operator (LASSO) regression were plotted with the minimum criteria. (C) Analysis of MFN2 expression in tumor and normal tissues based on the TCGA database. (D) Kaplan–Meier analysis to explore the effect of MFN2 expression on disease-free interval (DFI). The red color indicates copy-number deletion, and the blue color indicates copy-number increase or no change. (E) The receiver operating characteristic (ROC) curve shows the potential of the MFN2 copy-number deletion in predicting 1-, 3-, and 5-year DFI.

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