Table 2 Logistic association regression analysis of TERT SNPs with glioma.

From: A novel variant of telomerase reverse transcriptase (TERT) associated with risk of glioma in a Korean population

rs#

Coordinate

Alleles

Position

MAF in control (n = 480)

MAF in Glioma (n = 317)

OR (95% CI)

P

rs2736109

1,296,759

G > A

Upstream

0.252

0.270

1.16 (0.91–1.47)

0.228

rs7712562

1,296,072

G > A

Upstream

0.094

0.126

1.44 (1.04–1.99)

0.029

rs2736098

1,294,086

G > A

Exon2 (A305A)

0.320

0.325

1.09 (0.87–1.35)

0.468

rs2853672

1,292,983

T > G

Intron

0.413

0.451

1.22 (1.00-1.50)

0.053

rs2853676a

1,288,547

G > A

Intron

0.156

0.208

1.41 (1.09–1.82)

0.009

rs7710703

1,287,505

C > T

Intron

0.073

0.104

1.58 (1.08–2.30)

0.017

rs2736099

1,287,340

C > T

Intron

0.365

0.417

1.27 (1.04–1.56)

0.022

rs2853677a

1,287,194

T > C

Intron

0.327

0.377

1.32 (1.07–1.63)

0.011

rs34829399

1,287,002

C > T

Intron

0.055

0.066

1.24 (0.81–1.91)

0.328

rs2736100a

1,286,516

T > G

Intron

0.382

0.448

1.40 (1.14–1.73)

0.002

rs7705526

1,285,974

C > A

Intron

0.371

0.418

1.31 (1.06–1.61)

0.013

rs10866498

1,285,162

T > C

Intron

0.408

0.465

1.33 (1.08–1.63)

0.007

rs35029535

1,284,976

C > T

Intron

0.080

0.079

0.98 (0.67–1.43)

0.911

rs80276247

1,284,717

C > T

Intron

0.129

0.126

0.98 (0.72–1.33)

0.912

rs7713218

1,283,312

G > A

Intron

0.389

0.439

1.33 (1.08–1.64)

0.008

rs4975538a

1,280,830

G > C

Intron

0.344

0.398

0.74 (0.60–0.93)

0.008

rs13167280

1,280,477

G > A

Intron

0.144

0.140

0.99 (0.74–1.33)

0.939

rs2242652

1,280,028

C > T

Intron

0.198

0.258

1.45 (1.14–1.85)

0.003

rs10069690a

1,279,790

C > T

Intron

0.198

0.259

1.46 (1.15–1.86)

0.002

rs33963617

1,279,439

C > T

Exon5 (A699A)

0.046

0.031

0.69 (0.40–1.20)

0.187

rs2075785

1,278,584

G > A

Intron

0.458

0.401

0.81 (0.66-1.00)

0.047

rs33961405

1,277,577

G > A

Intron

0.395

0.368

0.91 (0.74–1.12)

0.377

rs56345976

1,276,873

G > A

Intron

0.254

0.322

1.41 (1.13–1.76)

0.002

rs56081816

1,273,905

G > A

Intron

0.076

0.088

1.17 (0.79–1.71)

0.436

rs562707895

1,273,610

G > T

Intron

0.408

0.403

1.02 (0.77–1.35)

0.882

rs13172201

1,271,661

C > T

Intron

0.154

0.165

1.08 (0.83–1.41)

0.566

rs4246742

1,267,356

A > T

Intron

0.363

0.294

0.77 (0.62–0.96)

0.023

rs3891054

1,267,202

G > C

Intron

0.363

0.297

0.76 (0.61–0.95)

0.017

rs2736115

1,264,068

G > A

Intron

0.071

0.079

1.19 (0.81–1.76)

0.372

rs35041195

1,257,288

G > A

Intron

0.224

0.215

1.00 (0.78–1.29)

0.989

rs33954691

1,255,520

C > T

Exon14 (H1013H)

0.317

0.292

0.9 (0.72–1.12)

0.338

rs2853691

1,252,950

A > G

Downstream

0.388

0.347

0.89 (0.72–1.10)

0.282

  1. Logistic regression analysis under the additive model was used for calculating ORs and corresponding P-values for SNPs controlling age and sex as covariates.
  2. OR odds ratio, CI confidence interval.
  3. Significant associations (P < 0.01) are shown in boldface.
  4. aSNPs reported as to have significant associations with brain tumor risk in previous studies.
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