Fig. 11
From: In silico pan-cancer analysis of VRAC subunits and their prognostic roles in human cancers
Comprehensive functional mapping of LRRC8 protein interactions and activities using BioGRID and ShinyGO 0.80 analyses. (a) The interaction network of LRRC8B highlights its role in various protein transport activities, with particular emphasis on the regulation of volume-sensitive anion channels and the transport of nucleobase-containing compounds. (b) The network of LRRC8C highlights its involvement in receptor-mediated processes, with an enriched presence of G protein-coupled receptors and those integral to immune responses and chemotactic signalling. (c) The network of LRRC8D showing its involvement in neurotransmitter-gated ion channels, along with related enzymatic activities, including dolichyl-diphosphooligosaccharide protein glycotransferase and GTPase. (d) The network associated with LRRC8E shows its connectivity within protein folding mechanisms and ion channel regulation, with a central node representing protein folding chaperones and their associated cation and gated channels.
