Fig. 2

Partial dependence plots showing the marginal effect of the features on the predictions of the model: (A) serum level of aspartate aminotransferase (AST), (B) blood level of glucose, (C) systolic blood pressure (SBP), (D) serum level of high-density lipoprotein (HDL) cholesterol. Note that the SHAP value for RNFL thinning decreases toward negative values as the AST level increases (A), blood glucose level decreases (B), SBP decreases (C), and HDL increases (D). The effect of a reduced glucose level (B) and influence of SBP (C) had sharp cutoff values (~ 100 mg/dL and ~ 120 mmHg, respectively; dotted lines), with lower values associated with accelerated RNFL thinning.