Table 2 Multivariable adjusting Cox regression analysis to determine risk covariates for aortic dissection and aneurysm.

FQs exposure vs. non-FQs exposure

1.61 (1.45–1.78)

< 0.001

Age group, years

 < 40 (reference)

1

< 0.001

 40–55

2.21 (1.55–3.14)

 ≥ 55

9.39 (6.83–12.92)

Male vs. female

2.47 (2.23–2.74)

< 0.001

Comorbidities

 Hypertension

1.14 (1.02–1.28)

0.023

 Hyperlipidemia

0.97 (0.89–1.07)

0.565

 Hyperparathyroidism

0.84 (0.37–1.88)

0.669

 Diabetes mellitus

0.75 (0.68–0.83)

< 0.001

 Hepatobiliary disorders

0.75 (0.57–0.97)

0.031

 Kidney disease

0.93 (0.73–1.17)

0.508

 Cerebrovascular disease

1.30 (1.16–1.45)

< 0.001

 Ischemic stroke

1.12 (0.95–1.31)

0.183

 Chronic obstructive pulmonary disease

1.06 (0.96–1.17)

0.252

 Coronary artery disease

1.50 (1.16–1.93)

0.001

 Asthma

0.88 (0.79–0.97)

0.014

 Genital tract infection

1.03 (0.93–1.13)

0.608

 Soft tissue and bone infection

0.90 (0.82–0.98)

0.015

 Lower respiratory tract infection

0.97 (0.88–1.07)

0.532

 Septicemia

1.36 (1.20–1.54)

< 0.001

 Seizure

0.50 (0.25–1.01)

0.052

Medications

 ACEI/ARB

1.40 (1.24–1.58)

< 0.001

 Beta-blockers

1.36 (1.22–1.51)

< 0.001

 Calcium channel blocker

1.59 (1.44–1.75)

< 0.001

 Insulin

0.56 (0.45–0.70)

< 0.001

 NSAIDs

0.90 (0.82–0.98)

0.018

 Diuretics

0.82 (0.65–1.04)

0.101

 Oral steroids

1.75 (1.56–1.96)

< 0.001

 Intravenous steroids

4.29 (3.82–4.81)

< 0.001