Table 4 Refining the reaction parameters for synthesizing 3-((4-chlorophenyl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methyl-4-hydroxy-2H-chromen-2-one derivative.
| |||||
|---|---|---|---|---|---|
Entry | Solvent | Catalyst (g) | Temperature (°C) | Time (min) | Yield (%) |
1 | _ | _ | 100 | 60 | Trace |
2 | _ | 0.01 | 80 | 30 | 27 |
3 | _ | 0.02 | 80 | 25 | 38 |
4 | _ | 0.03 | 70 | 21 | 65 |
5 | _ | 0.04 | 80 | 16 | 86 |
6 | _ | 0.05 | 80 | 12 | 93 |
7 | _ | 0.06 | 80 | 11 | 93 |
8 | _ | 0.05 | 70 | 12 | 93 |
9 | _ | 0.05 | 60 | 15 | 85 |
10 | _ | 0.05 | 50 | 20 | 77 |
11 | EtOH | 0.05 | 70 | 23 | 86 |
12 | MeOH | 0.05 | Reflux | 35 | 55 |
13 | H2O | 0.05 | 70 | 35 | Trace |
14 | EtOH/H2O | 0.05 | 70 | 25 | 89 |
