Table 2 Laboratory parameters and FIB-4 index distribution stratified by 90-Day functional outcome in acute ischemic stroke patients undergoing mechanical thrombectomy.

From: Association of liver fibrosis−4 index with functional outcomes in chinese patients with acute ischemic stroke undergoing mechanical thrombectomy

Variables

90-day functional outcome

P value

Overall, N = 421

mRS 0-2, N = 167

mRS 3-6, N = 254

Hematological parameters

    

White blood cell, ×109/L

11.6 (9.8, 13.9)

10.7 (8.7, 12.5)

12.5 (10.3, 14.7)

<0.001

Neutrophil, ×109/L

10.0 (7.9, 12.0)

8.6 (6.9, 10.6)

10.7 (8.8, 12.8)

<0.001

Lymphocyte, ×109/L

1.05 (0.74, 1.38)

1.22 (0.92, 1.62)

0.93 (0.70, 1.21)

<0.001

Monocyte, ×109/L

0.60 (0.46, 0.74)

0.58 (0.46, 0.72)

0.61 (0.47, 0.78)

0.130

Red blood cell, ×1012/L

4.22 (3.80, 4.63)

4.29 (3.94, 4.63)

4.18 (3.72, 4.64)

0.056

Hemoglobin, g/L

130 (116, 141)

132 (118, 140)

127 (113, 142)

0.188

Platelet count, ×109/L

201 (169, 242)

210 (178, 249)

196 (160, 234)

0.013

Biochemical Markers

    

Total protein, g/L

65 (62, 70)

65 (62, 69)

65 (62, 70)

0.853

Albumin, g/L

37.0 (34.6, 39.4)

37.1 (35.5, 39.5)

37.0 (34.0, 39.3)

0.167

Triglycerides, mmol/L

1.09 (0.80, 1.44)

1.12 (0.87, 1.44)

1.07 (0.75, 1.45)

0.144

Total cholesterol, mmol/L

4.35 (3.64, 5.01)

4.40 (3.78, 4.92)

4.31 (3.54, 5.10)

0.525

HDL-C, mmol/L

1.17 (0.99, 1.32)

1.16 (1.00, 1.29)

1.18 (0.97, 1.35)

0.535

LDL-C, mmol/L

2.88 (2.28, 3.36)

2.94 (2.41, 3.37)

2.83 (2.19, 3.34)

0.227

FBG, mmol/L

7.47 (6.28, 9.46)

6.87 (5.75, 8.47)

7.94 (6.61, 9.98)

<0.001

Creatinine, μmol/L

74 (59, 88)

72 (58, 82)

75 (60, 92)

0.008

Uric acid, μmol/L

330 (269, 407)

318 (263, 381)

336 (273, 418)

0.037

ALT, U/L

16 (12, 23)

16 (12, 24)

16 (12, 22)

0.188

AST, U/L

25 (20, 31)

24 (19, 29)

26 (20, 36)

0.007

FIB-4 index (continuous)

2.02 (1.35, 3.01)

1.75 (1.18, 2.45)

2.30 (1.46, 3.33)

<0.001

FIB-4 index (quartiles), n (%)

  

<0.001

Q1 [0.169,1.35)

105 (24.94)

55 (32.93)

50 (19.69)

 

Q2 [1.35,2.02)

105 (24.94)

46 (27.54)

59 (23.23)

 

Q3 [2.02,3.01)

105 (24.94)

47 (28.14)

58 (22.83)

 

Q4 [3.01,14.2]

106 (25.18)

19 (11.38)

87 (34.25)

 

FIB-4 index categories, n (%)

  

<0.001

Minimal fibrosis

89 (21.14)

50 (29.94)

39 (15.35)

 

Significant fibrosis

191 (45.37)

87 (52.10)

104 (40.94)

 

Advanced fibrosis

141 (33.49)

30 (17.96)

111 (43.70)

 
  1. Values are expressed as median (IQR) for non-normally distributed continuous variables and n (%) for categorical variables. Continuous variables were compared using Mann-Whitney U test due to non-normal distribution. Categorical variables were compared using chi-square test. Bold P values indicate statistical significance (P<0.05). FIB-4 index was calculated as: (Age × AST)/(Platelet count × √ALT). FIB-4 categories were stratified according to a recent meta-analysis and Chinese guidelines for metabolic dysfunction-associated fatty liver disease: minimal fibrosis (FIB-4 ≤1.30), significant fibrosis (1.30< FIB-4 <2.67), and advanced fibrosis (FIB-4 ≥2.67). Abbreviations: mRS, modified Rankin Scale; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; FBG, fasting blood glucose; ALT, alanine aminotransferase; AST, aspartate aminotransferase; FIB-4, Fibrosis-4 index.
Back to article page