Table 4 Logistic regression model for FIB-4 index and poor functional outcome at 90 days after mechanical thrombectomy.

Variables	Model 1		Model 2		Model 3
Variables	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
FIB-4 index (continuous)	1.58 (1.34, 1.91)	<0.001	1.37 (1.14, 1.70)	0.002	1.38 (1.11, 1.77)	0.013
FIB-4 index (quartiles)
Q1 [0.169,1.35)	Reference		Reference		Reference
Q2 [1.35,2.02)	1.41 (0.82, 2.43)	0.214	1.27 (0.71, 2.29)	0.417	1.42 (0.68, 2.96)	0.345
Q3 [2.02,3.01)	1.36 (0.79, 2.34)	0.270	0.79 (0.41, 1.53)	0.486	0.81 (0.33, 1.98)	0.648
Q4 [3.01,14.2]	5.04 (2.69, 9.43)	<0.001	2.93 (1.38, 6.22)	0.005	3.13 (1.06, 9.30)	0.040
P for trend		<0.001		0.027		0.110
FIB-4 index categories
Minimal fibrosis	Reference		Reference		Reference
Significant fibrosis	1.53 (0.92, 2.54)	0.098	1.21 (0.69, 2.13)	0.504	1.35 (0.65, 2.80)	0.425
Advanced fibrosis	4.74 (2.65, 8.48)	<0.001	2.95 (1.43, 6.07)	0.003	3.29 (1.17, 9.25)	0.024
P for trend		<0.001		0.003		0.017

Poor functional outcome was defined as 90-day modified Rankin Scale score 3-6. Three models with progressive adjustment for potential confounders were constructed to evaluate the robustness of the association. Results are presented as odds ratios with 95% confidence intervals. Bold P values indicate statistical significance (P<0.05). Models were constructed with progressive adjustment for potential confounders: Model 1: Unadjuted Model 2: Adjusted for age, baseline NIHSS score, baseline GCS score, hyperlipidemia, and atrial fibrillation Model 3: Additionally adjusted for thrombectomy attempts, successful reperfusion (mTICI 2b-3), and laboratory parameters (white blood cell, neutrophil, lymphocyte, platelet count, fasting glucose, creatinine, and uric acid). Abbreviations: OR, odds ratio; CI, confidence interval; NIHSS, National Institutes of Health Stroke Scale; GCS, Glasgow Coma Scale; mTICI, modified Thrombolysis in Cerebral Infarction.

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