Table 3 Adjusted associations of NT-proBNP, hs-cTnT, and hs-cTnI with CKD, US individuals without known cardiovascular disease, NHANES 1999 to 2004.

From: Associations of cardiac biomarkers with chronic kidney disease and mortality in US individuals without prevalent cardiovascular disease

 

CKD, OR (95% CI)

Clinical cut point

Model 1: unadjusted

Model 2: adjusted

Model 3: adjusted

NT-proBNP, pg/mL

   

   < 125

1 (reference)

1 (reference)

1 (reference)

  125– < 300

3.56 (2.79, 4.55)

1.99 (1.53, 2.59)

1.65 (1.22, 2.25)

  300– < 450

8.44 (6.01, 11.90)

3.69 (2.58, 5.29)

2.13 (1.27, 3.58)

   ≥ 450

19.50 (13.90, 27.40)

7.31 (5.19, 10.30)

3.00 (1.96, 4.60)

  P for trend

 < 0.001

 < 0.001

 < 0.001

hs-cTnT, ng/L

   

   < 6

1 (reference)

1 (reference)

1 (reference)

  6– < 14

2.82 (2.39, 3.32)

1.97 (1.63, 2.38)

0.96 (0.71, 1.30)

   ≥ 14

13.40 (10.90, 16.60)

6.96 (5.22, 9.28)

1.79 (1.18, 2.72)

  P for trend

 < 0.001

 < 0.001

0.027

hs-cTnI, ng/L

   

  M, < 6; F, < 4

1 (reference)

1 (reference)

1 (reference)

  M, 6–12; F, 4–10

5.63 (4.62, 6.87)

2.59 (2.13, 3.15)

1.50 (1.06, 2.12)

  M, > 12; F, > 10

6.97 (4.88, 9.97)

3.95 (2.74, 5.70)

2.15 (0.98, 4.69)

  P for trend

 < 0.001

 < 0.001

0.009

  1. Model 1: non-adjusted.
  2. Model 2: adjusted for age, gender, race, and education level.
  3. Model 3: adjusted for age, gender, race, education level, smoking, BMI, hypertension, TC, TG, HDL-C, urea, Ua, FBG, HbA1c, hs-CRP, eGFR, albuminuria, diabetes, and medication use.
  4. OR: odds ratio. M: male; F: female.
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