Table 4 Associations* (Hazard Ratio [95% CI]) between NT-proBNP, hs-cTnT, and hs-cTnI and mortality (all-cause and cardiovascular mortality) in different CKD status, NHANES 1999–2004.

From: Associations of cardiac biomarkers with chronic kidney disease and mortality in US individuals without prevalent cardiovascular disease

 

All-Cause Mortality

Cardiovascular Mortality

Clinical cut point

CKD Status

CKD Status

 

No

Yes

No

Yes

NT-proBNP, pg/mL

 < 125

1 (Ref)

1 (Ref)

1 (Ref)

1 (Ref)

125– < 300

1.35(1.10–1.66)

1.28(1.04–1.58)

1.56(1.19–2.05)

1.46(1.01–2.10)

300– < 450

1.99(1.45–2.73)

1.52(1.12–2.05)

1.79(1.08–2.94)

1.66(1.04–2.66)

 ≥ 450

2.40(1.81–3.18)

2.00(1.56–2.56)

2.02(1.29–3.15)

2.38(1.61–3.51)

hs-cTnT, ng/L

 < 6

1 (Ref)

1 (Ref)

1 (Ref)

1 (Ref)

6– < 14

1.43(1.20–1.69)

1.73(1.22–2.46)

1.16(0.84–1.60)

1.87(0.99–3.54)

 ≥ 14

2.10(1.71–2.58)

2.89(1.96–4.26)

1.51(1.01–2.30)

2.70(1.35–5.40)

hs-cTnI, ng/L

M, < 6; F, < 4

1 (Ref)

1 (Ref)

1 (Ref)

1 (Ref)

M, 6–12; F, 4–10

1.48(1.26–1.73)

1.44(1.23–1.68)

1.45(1.08–1.96)

1.31(0.98–1.75)

M, > 12; F, > 10

1.58(1.08–2.31)

1.92(1.50–2.44)

1.47(0.88–2.45)

2.11(1.46–3.04)

  1. *adjusted for age, gender, race, education level, smoking, BMI, hypertension, TC, TG, HDL-C, urea, Ua, FBG, HbA1c, hs-CRP, eGFR, albuminuria, diabetes, and medication use.
  2. M: male; F: female.
Back to article page