Table 2 Comparison of laboratory indicators between non-SALD and SALD groups on days 1 and 3.

From: Association and dynamic change of fecal calprotectin with sepsis associated liver dysfunction in adults with sepsis

Variables

Reference range

Total (n = 95)

Non-SALD group (n = 62)

SALD group (n = 33)

p

Laboratory indicators on day 1

  WBC count, median (IQR), 103/μL

3.50–9.50

10.60 (6.60, 16.00)

9.90 (6.05, 14.00)

13.50 (8.40, 19.60)

0.017

  Neutrophil count, median (IQR), 103/μL

1.80–6.30

8.70 (5.80, 14.50)

8.20 (5.20, 12.00)

12.10 (6.77, 17.88)

0.010

  Lymphocyte count, median (IQR), 103/μL

1.10–3.20

0.63 (0.46, 1.20)

0.70 (0.48, 1.13)

0.60 (0.44, 1.20)

0.769

  Procalcitonin, median (IQR), ng/mL

 < 0.50

0.99 (0.19, 7.89)

0.76 (0.16, 6.72)

1.31 (0.35, 11.05)

0.302

  C-reactive protein, median (IQR), mg/L

 < 6.00

93.50 (48.30, 152.40)

91.45 (44.98, 149.35)

98.20 (52.40, 153.50)

0.725

  IL-6, median (IQR), pg/mL

 < 6.80

144.15 (59.63, 335.22)

123.40 (53.07, 332.56)

209.50 (88.55, 335.22)

0.344

  IL-1β, median (IQR), pg/mL

 < 6.50

1.99 (0.86, 3.69)

1.56 (0.79, 3.48)

2.78 (1.33, 4.00)

0.142

  IL-2, median (IQR), pg/mL

 < 5.20

1.11 (0.60, 2.47)

1.12 (0.51, 2.33)

1.11 (0.75, 2.61)

0.894

  IL-4, median (IQR), pg/mL

 < 4.50

2.81 (1.68, 6.36)

2.51 (1.47, 6.14)

4.34 (2.44, 8.15)

0.170

  IL-5, median (IQR), pg/mL

 < 4.00

1.40 (0.88, 3.86)

1.23 (0.75, 3.86)

2.40 (1.15, 3.86)

0.405

  IL-8, median (IQR), pg/mL

 < 8.00

87.13 (48.85, 92.61)

87.13 (41.97, 88.37)

87.13 (63.24, 123.31)

0.213

  IL-10, median (IQR), pg/mL

 < 4.20

11.54 (6.76, 32.34)

11.54 (6.56, 30.81)

11.54 (7.17, 34.63)

0.577

  IL-17, median (IQR), pg/mL

 < 6.50

10.27 (4.64, 14.62)

10.27 (4.26, 14.34)

10.78 (6.05, 20.44)

0.338

  IFN-α, median (IQR), pg/mL

 < 8.50

1.34 (0.60, 1.65)

1.34 (0.62, 1.51)

1.34 (0.60, 1.80)

0.693

  IFN-γ, median (IQR), pg/mL

 < 5.50

14.56 (6.61, 24.79)

14.39 (6.61, 24.19)

16.15 (7.92, 25.75)

0.405

  TNF-α, median (IQR), pg/mL

 < 6.10

2.22 (1.00, 5.00)

2.22 (1.10, 5.00)

2.22 (0.97, 4.88)

0.953

  D-dimer, median (IQR), mg/L

 < 0.50

3.40 (2.05, 9.56)

3.12 (1.83, 8.05)

3.88 (2.35,15.84)

0.138

  BNP, median (IQR), pg/mL

5–100

163.00 (64.33, 427.50)

163.00 (71.40, 449.00)

174.00 (40.25, 401.00)

0.726

  Platelets, median (IQR), 103/μL

125–360

162.50 (104.25, 239.50)

170.00 (117.00, 246.00)

141.00 (93.00, 182.00)

0.044

  Albumin, median (IQR), g/L

40–55

27.05 (21.65, 29.13)

27.20 (24.45, 29.25)

26.00 (19.40, 28.60)

0.128

  HLA-DR, median (IQR), %

80–100

32.00 (16.70, 54.65)

34.50 (17.80, 54.20)

29.90 (16.10, 54.70)

0.897

  FC1, median (IQR), μg/g

 < 50.00

374.00 (110.48, 989.00)

342.00 (130.38, 872.00)

520.00 (59.04, 1000.00)

0.894

Laboratory indicators on day 3

  WBC count, median (IQR), 103/μL

–

11.10 (7.70, 14.70)

10.05 (7.13, 13.53)

12.80 (9.50, 16.95)

0.028

  Neutrophil count, median (IQR), 103/μL

–

9.10 (6.10, 12.30)

8.55 (5.43, 11.23)

10.20 (7.95, 14.40)

0.011

  Lymphocyte count, median (IQR), 103/μL

–

0.70 (0.40, 1.20)

0.70 (0.50, 1.20)

0.60 (0.35, 1.05)

0.081

  Procalcitonin, median (IQR), ng/mL

–

0.97 (0.27, 4.49)

0.54 (0.18, 2.15)

2.08 (1.02, 7.05)

 < 0.001

  C-reactive protein, median (IQR), mg/L

–

72.10 (32.65, 127.25)

71.05 (34.47, 122.10)

79.60 (33.00, 140.60)

0.563

  IL-6, median (IQR), pg/mL

–

103.16 (35.80, 446.34)

71.97 (32.08, 233.12)

320.34 (87.93, 654.77)

0.020

  FC3, median (IQR), μg/g

–

383.40 (113.14, 667.45)

252.35 (104.46, 526.18)

967.21 (339.07, 1000.00)

 < 0.001

  ΔFC, median (IQR), μg/g

–

 − 17.60( − 196.00, 112.45)

 − 137.93 ( − 309.81, 7.04)

200.42 (0.00, 327.45)

 < 0.001

  ΔFC percentage, median (IQR), %

–

 − 3.28( − 54.36, 67.72)

 − 36.40 ( − 61.02, 5.08)

56.00 (0.00, 465.12)

 < 0.001

  1. SALD Sepsis associated liver dysfunction; WBC White blood cell; IQR, Interquartile range; IL-6 Interleukin 6; IL-1β Interleukin 1β; IL-2 Interleukin 2; IL-4 Interleukin 4; IL-5 Interleukin 5; IL-8 Interleukin 8; IL-10 Interleukin 10; IL-17 Interleukin 17; IFN-α Interferon α; IFN-γ Interferon γ; TNF-α Tumor necrosis factor α; BNP B-type natriuretic peptide; HLA-DR Human leukocyte antigen DR; SD Standard deviation; FC1 Fecal calprotectin on day 1; FC3 Fecal calprotectin on day 3; ∆FC Change in fecal calprotectin between day 1 and day 3; ΔFC percentage, (calculated by dividing ΔFC by FC1 and multiplying by 100).
  2. Significant values are in bold.
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