Table 2 Longitudinal association of CHARLS modified frailty index (CMFI) and biological age (BA) with COPD.

From: Joint association of frailty index and biological age with chronic obstructive pulmonary disease: a cohort study from CHARLS

 

N

Event, (%)

Crude model

P

Model 1

P

Model 2

P

OR (95%CI)

OR (95%CI)

OR (95%CI)

BA (per SD)

  

1.20(1.11,1.30)

< 0.001

1.23(1.09,1.38)

0.001

1.24(1.08,1.41)

0.002

BA quartile

        

Q1 (< 50.44)

1612

107(6.6)

ref

 

ref

 

ref

 

Q2

(50.44–56.54)

1614

147(9.1)

1.41(1.09,1.83)

0.009

1.35(1.04,1.75)

0.024

1.33(1.02,1.73)

0.035

Q3

(56.55–63.30)

1612

174(10.8)

1.70(1.32,2.19)

< 0.001

1.64(1.27,2.12)

< 0.001

1.61(1.23,2.11)

< 0.001

Q4 (> 63.30)

1614

188(11.7)

1.85(1.45,2.38)

< 0.001

1.86(1.36,2.56)

< 0.001

1.94(1.37,2.75)

< 0.001

P for trend

   

< 0.001

 

< 0.001

 

< 0.001

CMFI (per SD)

  

1.31(1.22,1.40)

< 0.001

1.34(1.25,1.45)

< 0.001

1.32(1.23,1.43)

< 0.001

CMFI quartile

        

Q1 (< 0.056)

1584

87(5.5)

ref

 

ref

 

ref

 

Q2

(0.056–0.096)

1627

140(8.6)

1.62(1.23,2.14)

< 0.001

1.68(1.27,2.22)

< 0.01

1.65(1.25,2.18)

< 0.001

Q3

(0.097–0.151)

1644

178(10.9)

2.10(1.61,2.74)

< 0.001

2.26(1.73,2.96)

< 0.001

2.20(1.68,2.88)

< 0.001

Q4 (> 0.151)

1597

211(13.1)

2.61(2.01,3.38)

< 0.001

2.89(2.23,3.77)

< 0.001

2.78(2.12,3.65)

< 0.001

P for trend

   

< 0.001

 

< 0.001

 

< 0.001

  1. Crude model adjusted for nothing. Model I adjusted for gender and age. Model II adjusted for sex, age, body mass index, marital status, residence place, education, smoking, drinking, CRP (only in CMFI), and comorbidities (only in BA).
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