Fig. 5 | Scientific Reports

Fig. 5

From: The molecular characteristics of DNA damage and repair related to P53 mutation for predicting the recurrence and immunotherapy response in hepatocellular carcinoma

Fig. 5

The high-risk group demonstrated lower microenvironment score and decreased CD8 + T cell infiltration. (A) Box plots of four immune infiltration scores in the high and low-risk groups in the training and validation set. The asterisks represented the statistical P-value (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001). (B) Box plot of the scores of five immune infiltration algorithms in the high and low-risk groups of the TCGA cohort. The asterisks represented the statistical P-value (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001). (C) CyTOF plot of Xiangya cohort of immune infiltration in the high and low-risk groups. (D) Quantitative analysis of the proportion of immune cells in the high and low-risk groups in the Xiangya cohort. The asterisks represented the statistical P-value (*P < 0.05). (E) CyTOF plot of Xiangya cohort of CD8 + T cell infiltration and exhausted CD8 + T cell infiltration in the high and low-risk groups. (F) Quantitative analysis of the proportion of CD8 + T cells and the proportion of exhausted CD8 + T cells in the high and low-risk groups of the Xiangya cohort. The asterisks represented the statistical P-value (*P < 0.05).

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