Fig. 1
Examines the impact of lipids on intervertebral disc degeneration using Mendelian randomization forest plots and Bayesian model averaging. The IVW method computed odds ratios (OR), P-values (P-val), and 95% confidence intervals (CI). Bayesian odds ratios (B-OR) and Bayesian P-values (B-Pval) were derived from MR-BMA analysis, while IVW outcomes were depicted visually via forest plots. Phosphatidylcholine (O-16:1/20:3), characterized by specific molecular structure, comprises a choline head group linked to the glycerol backbone, incorporating a 16-carbon unsaturated fatty acid at the first position and a 20-carbon unsaturated fatty acid at the second position. The arrangement and composition of these components are pivotal for the structural and functional integrity of phospholipids within biological membranes. This naming convention similarly applies to phosphatidylethanolamine and phosphatidylinositol. In lipid terminology, "triacylglycerol 58:7" specifies the composition of triacylglycerol molecules, where “58” denotes the total carbon atoms in the three fatty acid chains, and "7" represents the total double bonds within these chains.
